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Behavior of Complex Knots in Single DNA Molecules

Bao, Xiaoyan R. and Lee, Heun Jin and Quake, Stephen R. (2003) Behavior of Complex Knots in Single DNA Molecules. Physical Review Letters, 91 (26). Art. No. 265506. ISSN 0031-9007. http://resolver.caltech.edu/CaltechAUTHORS:BAOprl03

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Abstract

We used optical tweezers to tie individual DNA molecules in knots. Although these knots become highly localized under tension, they remain surprisingly mobile and undergo thermal diffusion with classical random walk statistics. The diffusion constants of knots with different complexities correlate with theoretical calculations of knot sizes. We show that this correlation can be explained by a simple hydrodynamical model of "self-reptation" of the knot along a polymer.


Item Type:Article
Additional Information:©2003 The American Physical Society (Received 1 August 2003; published 31 December 2003) We thank D.E. Smith, P. Pieranski, M. Wang, and J. Su for helpful discussion, and J.-C. Meiners, K. Matthews, and A. Groisman for help with preliminary experiments. This work was funded in part by a grant from the Packard Foundation; X.R.B. thanks the Hertz Foundation for financial support. See Also: * Phys. Rev. Focus 12, story 25 <http://focus.aps.org/story/v12/st25> * Erratum: Xiaoyan R. Bao et al. Phys. Rev. Lett. 95, 199901 (E) (2005)
Subject Keywords:DNA; radiation pressure; thermal diffusion; molecular configurations
Record Number:CaltechAUTHORS:BAOprl03
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BAOprl03
Alternative URL:http://dx.doi.org/10.1103/PhysRevLett.91.265506
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6876
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:30 Dec 2006
Last Modified:26 Dec 2012 09:26

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