Hotta, Yoshiki and Benzer, Seymour (1970) Genetic Dissection of the Drosophila Nervous System by means of Mosaics. Proceedings of the National Academy of Sciences of the United States of America, 67 (3). pp. 1156-1163. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:HOTpnas70
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Given a mutant having abnormal behavior, the anatomical domain responsible for the deficit may be identified by the use of genetic mosaicism. Individuals may be produced in which a portion of the body is mutant male while the rest is normal female. In such sex mosaics, or gynandromorphs, the division line between normal and mutant parts can occur in various orientations. Mutants of five different genes (cistrons) on the X-chromosome of Drosophila melanogaster, having various abnormalities in visual function, have been tested by this method. All of these have been found to be autonomous, i.e., a mutant eye always functions abnormally, regardless of the amount of normal tissue present elsewhere, indicating that the primary causes of the behavioral deficits in these mutants are within the eye.
|Additional Information:||Copyright © 1970 by the National Academy of Sciences Communicated August 25, 1970 This work was supported by grant GB-8293 from the National Science Foundation. We are indebted to Dr. John R. Merriam for advice and stimulating discussion on the genetics and development of gynandromorphs, and to Lydia Yuan for histological studies.|
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|Deposited On:||01 Jan 2007|
|Last Modified:||26 Dec 2012 09:26|
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