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Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia

Daley, George Q. and Van Etten, Richard A. and Baltimore, David (1991) Blast Crisis in a Murine Model of Chronic Myelogenous Leukemia. Proceedings of the National Academy of Sciences of the United States of America, 88 (24). pp. 11335-11338. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:DALpnas91

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Abstract

The P210bcr/abl protein is produced in cells from patients with Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Retroviral transfer of the gene encoding P210bcr/abl into murine bone marrow induces a granulocytic leukemia that models the chronic phase of human CML. We have transferred the leukemic clone to syngeneic animals, albeit with surprising inefficiency, and have observed CML and clonally related acute leukemias of lymphoid or myeloid phenotype in some transplant recipients. These data show that murine CML can result from retroviral transfer of the bcr/abl gene into pluripotent hematopoietic stem cells, that infected clones repopulate poorly after adoptive transfer, and that these clones can give rise to acute leukemia, reflecting evolution to a phase resembling blast crisis in the human disease.


Item Type:Article
Additional Information:Copyright © 1991 by National Academy of Sciences Contributed by David Baltimore, September 9, 1991 We thank Drs. Richard C. Mulligan and Glen Dranoff for critical comments on the data and review of the manuscript. This work was funded in part by National Institutes of Health Grant CA51462-02 and by a grant from the Lucille P. Markey Charitable Trust. R.A.V. is a Lucille P. Markey Scholar. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:bcr/abl; Abelson murine leukemia virus; hematopoietic stem cell
Record Number:CaltechAUTHORS:DALpnas91
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:DALpnas91
Alternative URL:http://www.pnas.org/cgi/content/abstract/88/24/11335
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:6984
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:04 Jan 2007
Last Modified:14 Nov 2014 19:19

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