McCaffrey, Ronald and Smoler, Donna F. and Baltimore, David (1973) Terminal Deoxynucleotidyl Transferase in a Case of Childhood Acute Lymphoblastic Leukemia. Proceedings of the National Academy of Sciences of the United States of America, 70 (2). pp. 521-525. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:MCCpnas73
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Cells from a patient with childhood acute lymphoblastic leukemia contain an apparent DNA polymerase activity that was not found in any other cells except thymus cells. The enzyme has the properties of terminal transferase, an enzyme known to be found in thymocytes. The cells also contain the three major DNA polymerases found in growing cells. The results suggest that these tumor cells arose from a block in the differentiation of thymocytes. Terminal transferase may be a marker for the origin of leukemic cells.
|Additional Information:||Copyright © 1973 by the National Academy of Sciences Communicated by S. E. Luria, December 6, 1972 We thank Dr. David G. Nathan for his generous support and encouragement and for providing the clinical data and the cells from the patients with lymphoblastic and myeloblastic leukemia. We are grateful to Dr. J. Glass for the clinical data and cells from the patient with lymphosarcoma cell leukemia. Part of this work was performed while R.M. was a Trainee in Hematology at the Children's Hospital Medical Center, Boston, Mass. The work was supported by Grants AM-05581 and CA-13472 from the National Institutes of Health, Grant E-512 from the American Cancer Society, and a Contract from the Special Virus Cancer Program. D.B. was a Faculty Research Awardee of the American Cancer Society.|
|Subject Keywords:||thymocytes; DNA polymerases|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||06 Jan 2007|
|Last Modified:||26 Dec 2012 09:28|
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