CaltechAUTHORS
  A Caltech Library Service

Terminal Deoxynucleotidyl Transferase in a Case of Childhood Acute Lymphoblastic Leukemia

McCaffrey, Ronald and Smoler, Donna F. and Baltimore, David (1973) Terminal Deoxynucleotidyl Transferase in a Case of Childhood Acute Lymphoblastic Leukemia. Proceedings of the National Academy of Sciences of the United States of America, 70 (2). pp. 521-525. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:MCCpnas73

[img]
Preview
PDF
See Usage Policy.

1026Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:MCCpnas73

Abstract

Cells from a patient with childhood acute lymphoblastic leukemia contain an apparent DNA polymerase activity that was not found in any other cells except thymus cells. The enzyme has the properties of terminal transferase, an enzyme known to be found in thymocytes. The cells also contain the three major DNA polymerases found in growing cells. The results suggest that these tumor cells arose from a block in the differentiation of thymocytes. Terminal transferase may be a marker for the origin of leukemic cells.


Item Type:Article
Additional Information:Copyright © 1973 by the National Academy of Sciences Communicated by S. E. Luria, December 6, 1972 We thank Dr. David G. Nathan for his generous support and encouragement and for providing the clinical data and the cells from the patients with lymphoblastic and myeloblastic leukemia. We are grateful to Dr. J. Glass for the clinical data and cells from the patient with lymphosarcoma cell leukemia. Part of this work was performed while R.M. was a Trainee in Hematology at the Children's Hospital Medical Center, Boston, Mass. The work was supported by Grants AM-05581 and CA-13472 from the National Institutes of Health, Grant E-512 from the American Cancer Society, and a Contract from the Special Virus Cancer Program. D.B. was a Faculty Research Awardee of the American Cancer Society.
Subject Keywords:thymocytes; DNA polymerases
Record Number:CaltechAUTHORS:MCCpnas73
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:MCCpnas73
Alternative URL:http://www.pnas.org/cgi/content/abstract/70/2/521
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7044
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:06 Jan 2007
Last Modified:26 Dec 2012 09:28

Repository Staff Only: item control page