CaltechAUTHORS
  A Caltech Library Service

High Molecular Weight Nonribosomal-Type Nuclear RNA and Cytoplasmic Messenger RNA in Hela Cells

Houssais, Jean-François and Attardi, Giuseppe (1966) High Molecular Weight Nonribosomal-Type Nuclear RNA and Cytoplasmic Messenger RNA in Hela Cells. Proceedings of the National Academy of Sciences of the United States of America, 56 (2). pp. 616-623. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:HOUpnas66

[img]
Preview
PDF
See Usage Policy.

1031Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:HOUpnas66

Abstract

As reported elsewhere,[1] the study of RNA synthesis in vitro in immature duck erythrocytes has revealed the occurrence in the nucleus of fast turning-over RNA of high molecular weight (from 2 X 10^6 to 10^7, or possibly more) and with base composition different from that of ribosomal RNA, and characterized by a high U and relatively low GC content. No relationship of precursor-to-product type -- or, at any rate, not a simple one-appears to exist between this RNA and the messenger RNA fraction associated with cytoplasmic polysomes. In this paper, evidence is presented indicating that this class of nuclear RNA molecules is not exclusive of immature erythrocytes, or in general of nondividing cells undergoing differentiation, but occurs also in exponentially growing cells.


Item Type:Article
Additional Information:Copyright © 1966 by National Academy of Sciences Commnunicated by Norman Davidson, May 23, 1966. This work was supported by a research grant from the U.S. Public Health Service (GM-11726). One of the authors (J.-F. Houssais) is a Fellow of Comite de Biologie Moleculaire, Delegation General a la Recherche Scientifique et Technique, Paris, France. The authors would like to thank Mrs. LaVerne Wenzel and Mrs. Benneta Keeley for their excellent assistance.
Record Number:CaltechAUTHORS:HOUpnas66
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HOUpnas66
Alternative URL:http://www.pnas.org/cgi/reprint/56/2/616
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:707
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:15 Sep 2005
Last Modified:26 Dec 2012 08:41

Repository Staff Only: item control page