Newman, Dianne (2016) Pathogen Growth Rates in CF Sputum are Slow and Heterogeneous: Implications for Research and Treatment Strategies. Pediatric Pulmonology, 51 (S45). p. 162. ISSN 8755-6863. http://resolver.caltech.edu/CaltechAUTHORS:20161111-085149507
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Conventionally, microorganisms are grown in the laboratory under conditions where doubling times are less than an hour. While it is well appreciated that microbes experience nutrient limitation in nature, we know very little about how quickly they are growing or what limits them in any particular environment. This is particularly true in chronic infections, yet our ignorance of these environments (and the ensuing physiological response of pathogens) is one of the main reasons current antibiotic treatments are not fully effective. In collaboration with clinicians at Children’s Hospital Los Angeles and geochemists and bioengineers at Caltech, we have been developing and applying new methods to better characterize the chemical and biological states that occur in CF sputum. Such information is necessary to design relevant laboratory experiments to elucidate pathogen survival strategies in vivo. I will discuss the implications our findings for treating CF infections.
|Additional Information:||© 2016 Wiley. First published: 21 September 2016.|
|Official Citation:||(2016), Symposium Summaries. Pediatr Pulmonol., 51: S115–S193. doi:10.1002/ppul.23575|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||16 Nov 2016 00:33|
|Last Modified:||16 Nov 2016 00:33|
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