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A Proton Magnetic Resonance Study of The Interaction of Adenosine with Polyuridylic Acid: Evidence for Both Adenine-Uracil Base-Stacking and Base-Pairing

Bangerter, Benedict W. and Chan, Sunney I. (1968) A Proton Magnetic Resonance Study of The Interaction of Adenosine with Polyuridylic Acid: Evidence for Both Adenine-Uracil Base-Stacking and Base-Pairing. Proceedings of the National Academy of Sciences of the United States of America, 60 (4). pp. 1144-1151. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:BANpnas68

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Abstract

We report here a proton magnetic resonance (pmr) study of the interaction of adenosine with polyuridylic acid in aqueous solution. The results of this study indicate that the mode of interaction is adenosine intercalation and adenine-uracil base-stacking above 26[degrees]C, and verifies that a triple-stranded complex which is stabilized by both adenine-uracil hydrogen-bonding and adenine-adenine base-stacking is formed below this temperature. Some information regarding the dynamics of these processes has also been obtained.


Item Type:Article
Additional Information:Copyright © 1968 by the National Academy of Sciences Communicated by Norman Davidson, May 15, 1968 This work was supported in part by grant GM-14523-02, U.S. Public Health Service. Noyes Laboratory of Chemical Physics, Contribution no. 3676.
Record Number:CaltechAUTHORS:BANpnas68
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BANpnas68
Alternative URL:http://www.pnas.org/cgi/reprint/60/4/1144
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:723
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:20 Sep 2005
Last Modified:14 Nov 2014 19:18

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