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Template activity of liver chromatin increased by in vivo administration of insulin

Morgan, Carl R. and Bonner, James (1970) Template activity of liver chromatin increased by in vivo administration of insulin. Proceedings of the National Academy of Sciences of the United States of America, 65 (4). pp. 1077-1080. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:MORpnas70

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Abstract

The hypothesis that insulin may serve as a derepressor of genetic information in the liver of diabetic rats has been tested by comparing the template activity for RNA synthesis of chromatin from liver of insulin-treated diabetic rats to that of chromatin from liver of insulin-deficient diabetic rats. The template activity of the chromatins of insulin-treated diabetic rats is found to be 28 per cent greater than that of chromatin from liver of diabetic rats not treated with insulin. Time course studies show that the template activity of liver chromatin of rats injected with a single dose of insulin reaches a peak at two hours, which is some hours before the appearance of a typical insulin-induced liver enzyme, glucokinase. We conclude that insulin derepresses genetic material of the diabetic liver genome that is repressed in the absence of insulin.


Item Type:Article
Additional Information:© 1970 by the National Academy of Sciences. Communicated January 19, 1970. This work was supported in part by grant GM 13762 from the U.S. Public Health Service. C.R. Morgan was the recipient of a U.S. Public Health Service Special Fellowship while on leave of absence from Indiana University.
Record Number:CaltechAUTHORS:MORpnas70
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:MORpnas70
Alternative URL:http://www.pnas.org/cgi/content/abstract/65/4/1077
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7450
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Feb 2007
Last Modified:26 Dec 2012 09:31

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