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Interspersion of repetitive and single-copy sequences in nuclear ribonucleic acid of high molecular weight

Holmes, David S. and Bonner, James (1974) Interspersion of repetitive and single-copy sequences in nuclear ribonucleic acid of high molecular weight. Proceedings of the National Academy of Sciences of the United States of America, 71 (4). pp. 1108-1112. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:HOLpnas74

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Abstract

Nuclear RNA of high molecular weight, approximately 15 to 30 x 10^(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were interspersed within the same molecule. or whether they were interspersed within the same molecule. The present communication distinguishes between these possibilities and shows that a large proportion of nuclear RNA of high molecular weight consists of interspersed middle repetitive and single-copy sequences.


Item Type:Article
Additional Information:© 1974 by the National Academy of Sciences. Contributed by James Bonner, December 7, 1973. This work was supported by U.S. Public Health Service Grant GM 13762 and the Lucy Mason Clark Fund of the California Institute of Technology.
Record Number:CaltechAUTHORS:HOLpnas74
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HOLpnas74
Alternative URL:http://www.pnas.org/cgi/content/abstract/71/4/1108
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7494
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Feb 2007
Last Modified:26 Dec 2012 09:32

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