Kluge, N. and Ostertag, W. and Sugiyama, T. and Arndt-Jovin, D. and Steinheider, G. and Furusawa, M. and Dube, S. K. (1976) Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene. Proceedings of the National Academy of Sciences of the United States of America, 73 (4). pp. 1237-1240. ISSN 0027-8424. PMCID PMC430237. http://resolver.caltech.edu/CaltechAUTHORS:KLUpnas76
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Permanent cell lines from transplantable tumors from 7,12-dimethylbenz(a)anthracene-induced erythroleukemia of the rat were established. These cell lines maintain their erythroid nature. Erythroid differentiation can be induced by dimethylsulfoxide. This is shown by decrease in cell size, appearance of red and benzidine positive cells, and induced synthesis of four out of six adult globin chains.
|Additional Information:||© 1976 National Academy of Sciences. Communicated by Charles Huggins, January 2, 1976. We thank Mrs. A. Rohmann and Mrs. U. Ries for assistance. The work was supported by a research stipend (G.S.) and by a grant (W.O.) from the Deutsche Forschungsgemeinschaft.|
|Subject Keywords:||erythropoiesis; cell size analysis; Friend virus; Friend cells|
|PubMed Central ID:||PMC430237|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||01 Mar 2007|
|Last Modified:||18 Apr 2017 02:12|
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