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Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene

Kluge, N. and Ostertag, W. and Sugiyama, T. and Arndt-Jovin, D. and Steinheider, G. and Furusawa, M. and Dube, S. K. (1976) Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene. Proceedings of the National Academy of Sciences of the United States of America, 73 (4). pp. 1237-1240. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:KLUpnas76

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Abstract

Permanent cell lines from transplantable tumors from 7,12-dimethylbenz(a)anthracene-induced erythroleukemia of the rat were established. These cell lines maintain their erythroid nature. Erythroid differentiation can be induced by dimethylsulfoxide. This is shown by decrease in cell size, appearance of red and benzidine positive cells, and induced synthesis of four out of six adult globin chains.


Item Type:Article
Additional Information:© 1976 by the National Academy of Sciences. Communicated by Charles Huggins, January 2, 1976. We thank Mrs. A. Rohmann and Mrs. U. Ries for assistance. The work was supported by a research stipend (G.S.) and by a grant (W.O.) from the Deutsche Forschungsgemeinschaft.
Subject Keywords:erythropoiesis; cell size analysis; Friend virus; Friend cells
Record Number:CaltechAUTHORS:KLUpnas76
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KLUpnas76
Alternative URL:http://www.pnas.org/cgi/content/abstract/73/4/1237
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7522
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Mar 2007
Last Modified:26 Dec 2012 09:32

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