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Isolation of the fundamental polypeptide subunits of biological membranes

Laico, Marion T. and Ruoslahti, Erkki I. and Papermaster, David S. and Dreyer, William J. (1970) Isolation of the fundamental polypeptide subunits of biological membranes. Proceedings of the National Academy of Sciences of the United States of America, 67 (1). pp. 120-127. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:LAIpnas70

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Abstract

A group of peptides (some or all of them glycopeptides), of molecular weight about 5000, has been shown to be a major fraction of biological membranes. These "miniproteins" have been prepared from membranes of human and bovine red blood cells, from purified bovine liver mitochondria, and from the rhodopsin-containing membranes of the outer segments of bovine retinal rods. While the miniproteins were found in large amounts in each case, the other protein components differed markedly depending on the function of the membrane studied. This fact was particularly clear in the case of the rod membranes where the only major proteins detected were the miniproteins and rhodopsin. The large size of the miniprotein fraction in each of these membranes leads us to propose that the miniproteins play a fundamental role in the several functions which occur as common denominators in biological membranes.


Item Type:Article
Additional Information:© 1970 by the National Academy of Sciences. Communicated by Max Delbrück, June 29, 1970. We wish to express our gratitude to Mrs. Uma Ramaswami, Mrs. Inge Frahm, and Mr. David Schemberger for their excellent technical assistance. We thank Dr. Max Delbrück for many stimulating discussions over the past years and, in particular, for his critical comments in relation to this manuscript. This work has been presented at a FASEB meeting.(19) It was supported by USPHS grant GM 06965. One of us is the recipient of a fellowship PF-527 of the American Cancer Society (D.P.) and another of USPHS fellowship 5-FO5-TW 1383 (E.R.).
Record Number:CaltechAUTHORS:LAIpnas70
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:LAIpnas70
Alternative URL:http://www.pnas.org/cgi/content/abstract/67/1/120
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7544
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Mar 2007
Last Modified:14 Nov 2014 19:19

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