Davidson, Eric H. and Haslett, G. W. and Finney, R. J. and Allfrey, V. G. and Mirsky, A. E. (1965) Evidence for prelocalization of cytoplasmic factors affecting gene activation in early embryogenesis. Proceedings of the National Academy of Sciences of the United States of America, 54 (3). pp. 696-704. ISSN 0027-8424. PMCID PMC219730. http://resolver.caltech.edu/CaltechAUTHORS:DAVpnas65
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Differentiation begins early in embryogenesis as different genes become active in different cells. Within the closed system of the early embryo, equal genomes thus direct the creation of diverse cell types. Though the nuclei of these cells contain complete copies of the same genome,(1,2) the nucleoplasmic and cytoplasmic environments of these genomes are not the same, as a result of the distribution of cleavage nuclei into diverse areas of egg cytoplasm early in the cleavage process. In some cases the fate of these nuclei, i.e., the type of differentiated cell to which they or their descendants give rise, has been seen to depend on the area of cytoplasm in which they come to lie.
|Additional Information:||© 1965 by the National Academy of Sciences. Communicated June 14, 1965. We are indebted to Dr. Jack Collier for his invaluable advice and assistance. This research was supported in part by the American Cancer Society (grant E-334) and by the U.S. Public Health Service (grant GM 04919).|
|PubMed Central ID:||PMC219730|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||05 Mar 2007|
|Last Modified:||17 Dec 2015 00:39|
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