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Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels

Britten, Roy J. (2002) Divergence between samples of chimpanzee and human DNA sequences is 5%, counting indels. Proceedings of the National Academy of Sciences of the United States of America, 99 (21). pp. 13633-13635. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:BRIpnas02

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Abstract

Five chimpanzee bacterial artificial chromosome (BAC) sequences (described in GenBank) have been compared with the best matching regions of the human genome sequence to assay the amount and kind of DNA divergence. The conclusion is the old saw that we share 98.5% of our DNA sequence with chimpanzee is probably in error. For this sample, a better estimate would be that 95% of the base pairs are exactly shared between chimpanzee and human DNA. In this sample of 779 kb, the divergence due to base substitution is 1.4%, and there is an additional 3.4% difference due to the presence of indels. The gaps in alignment are present in about equal amounts in the chimp and human sequences. They occur equally in repeated and nonrepeated sequences, as detected by REPEATMASKER (http://ftp.genome.washington.edu/RM/RepeatMasker.html).


Item Type:Article
Additional Information:© 2002 by the National Academy of Sciences. Contributed by Roy J. Britten, August 22, 2002. Published online before print October 4, 2002. I thank John Williams for help in data processing and DNA sequence comparisons.
Subject Keywords:base substitutions; insertion/deletion differences; DNA evolution
Record Number:CaltechAUTHORS:BRIpnas02
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:BRIpnas02
Alternative URL:http://dx.doi.org/10.1073/pnas.172510699
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7586
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Mar 2007
Last Modified:14 Nov 2014 19:19

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