Britten, Roy J. (1995) Active gypsy/Ty3 retrotransposons or retroviruses in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 92 (2). pp. 599-601. ISSN 0027-8424. PMCID PMC42789. http://resolver.caltech.edu/CaltechAUTHORS:BRIpnas95
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A gypsy/Ty3-class retrotransposon (Cer1) is integrated in the DNA of Caenorhabditis elegans chromosome III. It is 8865 nt in length and has 492-nt long terminal repeats that are identical in DNA sequence. There is an exceptionally long (6819 nt) open reading frame uninterrupted by frameshift mutations in the period since the insertion, which must therefore have been rather recent. Alignment with other gypsy-class elements and with retroviruses indicates that an env gene occupies the 3' 1.2 kb of the open reading frame. A search through GenBank has uncovered two additional gypsy-class elements from C. elegans that are very closely related in DNA sequence to this insert and are transcribed. Since gypsy of Drosophila has been shown to be an infectious element, it is possible that retrovirus-like gypsy elements are active in C. elegans.
|Additional Information:||© 1995 by the National Academy of Sciences. Contributed by Roy J. Britten, September 30, 1994. This work was supported by National Institutes of Health grants. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.|
|Subject Keywords:||NEMATODE; TRANSCRIPTION; REVERSE TRANSCRIPTION; MOBILE ELEMENTS|
|PubMed Central ID:||PMC42789|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||09 Mar 2007|
|Last Modified:||24 Dec 2015 16:48|
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