Oikonomou, Grigorios and Prober, David A. (2017) Attacking sleep from a new angle: contributions from zebrafish. Current Opinion in Neurobiology, 44 . pp. 80-88. ISSN 0959-4388. http://resolver.caltech.edu/CaltechAUTHORS:20170410-104149609
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Sleep consumes a third of our lifespan, but we are far from understanding how it is initiated, maintained and terminated, or what purposes it serves. To address these questions, alternative model systems have recently been recruited. The diurnal zebrafish holds the promise of bridging the gap between simple invertebrate systems, which show little neuroanatomical conservation with mammals, and well-established, but complex and nocturnal, murine systems. Zebrafish larvae can be monitored in a high-throughput fashion, pharmacologically tested by adding compounds into the water, genetically screened using transient transgenesis, and optogenetically manipulated in a non-invasive manner. Here we discuss work that has established the zebrafish as a powerful system for the study of sleep, as well as novel insights gained by exploiting its particular advantages.
|Additional Information:||© 2017 Elsevier Ltd. Available online 6 April 2017. We thank Catherine Oikonomou, Daniel Lee and Chanpreet Singh for comments on the manuscript. This work was supported by grants from the National Institutes of Health (NS070911, NS094390 and NS095824), the Mallinckrodt Foundation, the Rita Allen Foundation, and the Brain and Behavior Research Foundation to D.A.P., and from the National Institutes of Health (NS082010) and the Della Martin Foundation to G.O.|
|Official Citation:||Grigorios Oikonomou, David A Prober, Attacking sleep from a new angle: contributions from zebrafish, Current Opinion in Neurobiology, Volume 44, June 2017, Pages 80-88, ISSN 0959-4388, http://doi.org/10.1016/j.conb.2017.03.009. (http://www.sciencedirect.com/science/article/pii/S0959438816301696)|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||10 Apr 2017 17:58|
|Last Modified:||10 Apr 2017 17:58|
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