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Cytoplasmic DNA in the unfertilized sea urchin egg: Physical properties of circular mitochondrial DNA and the occurrence of catenated forms

Pikó, Lajos and Blair, Donald G. and Tyler, Albert and Vinograd, Jerome (1968) Cytoplasmic DNA in the unfertilized sea urchin egg: Physical properties of circular mitochondrial DNA and the occurrence of catenated forms. Proceedings of the National Academy of Sciences of the United States of America, 59 (3). pp. 838-845. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:PIKpnas68

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Abstract

The mitochondrial DNA in the unfertilized egg of the sea urchin Lytechinus pictus is present in an amount approximately seven times that of the haploid nuclear DNA.(1) The mitochondrial DNA has a higher buoyant density than the nuclear DNA and consists of circular duplex molecules of a uniform size of about 5µ. The circular DNA has been recovered(1) in both the intact (closed) and nicked (open) states characteristic of the circular duplex viral DNA's(2) and the mitochondrial DNA's from birds and mammals.(3, 4)


Item Type:Article
Additional Information:© 1968 by the National Academy of Sciences. Communicated by Robert L. Sinsheimer, January 5, 1968. The authors wish to thank J. Jordan, R. Radloff, and R. Watson for advice and assistance, and P. N. Redington and E. E. Vivanco for technical contributions. This work was supported by grants GM-15327, 8R01 HD 03476, and CA-08014 from the U.S. Public Health Service and grant GB-28 from the National Science Foundation. Contribution 3628 from the Laboratories of Chemistry, California Institute of Technology, Pasadena, California.
Record Number:CaltechAUTHORS:PIKpnas68
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:PIKpnas68
Alternative URL:http://dx.doi.org/10.1073/pnas.59.3.838
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7693
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Mar 2007
Last Modified:14 Nov 2014 19:19

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