CaltechAUTHORS
  A Caltech Library Service

Antibody differentiation: Apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins

Sledge, C. and Fair, D. S. and Black, B. and Krueger, R. G. and Hood, L. (1976) Antibody differentiation: Apparent sequence identity between variable regions shared by IgA and IgG immunoglobulins. Proceedings of the National Academy of Sciences of the United States of America, 73 (3). pp. 923-927. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:SLEpnas76

[img]
Preview
PDF
See Usage Policy.

1022Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:SLEpnas76

Abstract

We have analyzed a pair of human myeloma immunoglobulins (biclonal proteins) of the IgG and IgA classes from a single patient, GR. The light chains are identical in amino-acid sequence over 40 residues at their NH2-terminus, whereas the heavy chains are identical throughout 45 residues of their NH2-terminus. Additional chemical and serological studies suggest the light chains and variable regions of the heavy chain (VH) are very similar, if not identical. The implications of these and of other published studies are discussed with regard to (i) the association of one VH region with multiple constant regions of the heavy chain (CH regions), (ii) two alternative types of V-C joining mechanisms, (iii) the differentiation of antibody-producing cells, and (iv) three categories of biclonal immunoglobulins.


Item Type:Article
Additional Information:© 1976 by the National Academy of Sciences. Communicated by William B. Wood, December 15, 1975. This work was supported by grants from the National Science Foundation and the National Institutes of Health. L.H. has a Research Career Development Award from NIH.
Subject Keywords:automatic sequenator; differentiation; variable-constant joining mechanisms; categories of biclonal immunoglobulins
Record Number:CaltechAUTHORS:SLEpnas76
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:SLEpnas76
Alternative URL:http://dx.doi.org/10.1073/pnas.73.3.923
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7711
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Aug 2007
Last Modified:14 Nov 2014 19:19

Repository Staff Only: item control page