Jiang, Huiping and Lyubarsky, Arkady and Dodd, Robert and Vardi, Noga and Pugh, Edward and Baylor, Denis and Simon, Melvin I. and Wu, Dianqing (1996) Phospholipase C beta 4 is involved in modulating the visual response in mice. Proceedings of the National Academy of Sciences of the United States of America, 93 (25). pp. 14598-14601. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:JIApnas96
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Expression of G protein-regulated phospholipase C (PLC) beta 4 in the retina, lateral geniculate nucleus, and superior colliculus implies that PLC beta 4 may play a role in the mammalian visual process. A mouse line that lacks PLC beta 4 was generated and the physiological significance of PLC beta 4 in murine visual function was investigated. Behavioral tests using a shuttle box demonstrated that the mice lacking PLC beta 4 were impaired in their visual processing abilities, whereas they showed no deficit in their auditory abilities. In addition, the PLC beta 4-null mice showed 4-fold reduction in the maximal amplitude of the rod a- and b-wave components of their electroretinograms relative to their littermate controls. However, recording from single rod photoreceptors did not reveal any significant differences between the PLC beta 4-null and wild-type littermates, nor were there any apparent differences in retinas examined with light microscopy. While the behavioral and electroretinographic results indicate that PLC beta 4 plays a significant role in mammalian visual signal processing, isolated rod recording shows little or no apparent deficit, suggesting that the effect of PLC beta 4 deficiency on the rod signaling pathway occurs at some stage after the initial phototransduction cascade and may require cell-cell interactions between rods and other retinal cells.
|Additional Information:||Copyright © 1996 by the National Academy of Sciences Contributed by Melvin I. Simon, October 7, 1996 We thank Yanping Wu, Jeannie Chen, Jun Xu, Jason Chen, and Shirley Pease for their generous help. This work is supported by grants from the National Institutes of Health to M.I.S. (AG 12288) and to D.W. (GM 53162). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.|
|Subject Keywords:||animal behavior, vision, transgenic mice, retinal function, visual response|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||30 Sep 2005|
|Last Modified:||19 Mar 2015 23:13|
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