Roles of phospholipase C β2 in chemoattractant-elicited responses
Abstract
The physiological roles of phospholipase C (PLC) beta 2 in hematopoiesis, leukocyte function, and host defense against infection were investigated using a mouse line that lacks PLC beta 2. PLC beta 2 deficiency did not affect hematopoiesis, but it blocked chemoattractant-induced Ca2+ release, superoxide production, and MAC-1 up-regulation in neutrophils. In view of these effects, it was surprising that the absence of PLC beta 2 enhanced chemotaxis of different leukocyte populations and sensitized the in vivo response of the PLC beta 2-deficient mice to bacteria, viruses, and immune complexes. These data raise questions about the roles that PLC beta 2 may play in signal transduction induced by chemoattractants in leukocytes.
Additional Information
© 1997 by the National Academy of Sciences Contributed by Melvin I. Simon, May 29, 1997 We thank Drs. James and Nancy Lee for critically reading the manuscript. This work was supported by grants from the Arthritis Foundation and the National Institutes of Health (GM54597 and GM53162 to D.W.; AG12288 to M.I.S.) and from the American Heart Association (to H.J.). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.Attached Files
Published - JIApnas97.pdf
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Additional details
- PMCID
- PMC21539
- Eprint ID
- 788
- Resolver ID
- CaltechAUTHORS:JIApnas97
- Arthritis Foundation
- NIH
- GM54597
- NIH
- GM53162
- NIH
- AG12288
- American Heart Association
- Created
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2005-09-30Created from EPrint's datestamp field
- Updated
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2019-10-02Created from EPrint's last_modified field