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Partially Mixed Selectivity in Human Posterior Parietal Association Cortex

Zhang, Carey Y. and Aflalo, Tyson and Revechkis, Boris and Rosario, Emily R. and Ouellette, Debra and Pouratian, Nader and Andersen, Richard A. (2017) Partially Mixed Selectivity in Human Posterior Parietal Association Cortex. Neuron, 95 (3). pp. 697-708. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20170721-073238920

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Abstract

To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single units coded for diverse conjunctions of variables, with different dimensions anatomically overlapping. Consistent with recent studies, neurons encoding body parts exhibited mixed selectivity. This mixed selectivity resulted in largely orthogonal coding of body parts, which “functionally segregate” the effector responses despite the high degree of anatomical overlap. Body side and strategy were not coded in a mixed manner as effector determined their organization. Mixed coding of some variables over others, what we term “partially mixed coding,” argues that the type of functional encoding depends on the compared dimensions. This structure is advantageous for neuroprosthetics, allowing a single array to decode movements of a large extent of the body.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neuron.2017.06.040DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627317305925PublisherArticle
Additional Information:© 2017 Elsevier Inc. Received 16 February 2017, Revised 5 June 2017, Accepted 24 June 2017, Available online 20 July 2017. Published: July 20, 2017. This work was supported by the National Institute of Health (R01EY015545), the Tianqiao and Chrissy Chen Brain-machine Interface Center at Caltech, the Della Martin Foundation, the Conte Center for Social Decision Making at Caltech (P50MH094258), and the Boswell Foundation. The authors would also like to thank subject N.S. for participating in the studies and Kelsie Pejsa, Tessa Yao, and Viktor Scherbatyuk for technical and administrative assistance. Author Contributions: C.Y.Z., T.A., and R.A.A. designed the study. C.Y.Z. and T.A developed the experimental tasks, collected data, and analyzed the results. C.Y.Z., T.A., and R.A.A. interpreted results and wrote the paper. B.R. provided technical support. E.R.R. provided experimental facilities and administrative assistance and coordination with Casa Colina Hospital and Centers for Healthcare. D.O. provided onsite assistance during experimental sessions. N.P. performed the surgery implanting the recording arrays in N.S.
Funders:
Funding AgencyGrant Number
NIHR01EY015545
CaltechUNSPECIFIED
Della Martin FoundationUNSPECIFIED
NIHP50MH094258
James G. Boswell FoundationUNSPECIFIED
Subject Keywords:Mixed selectivity; anterior intraparietal cortex; brain-machine interfaces; posterior parietal cortex; spinal cord injury; motor imagery; functional segregation
Record Number:CaltechAUTHORS:20170721-073238920
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170721-073238920
Official Citation:Carey Y. Zhang, Tyson Aflalo, Boris Revechkis, Emily R. Rosario, Debra Ouellette, Nader Pouratian, Richard A. Andersen, Partially Mixed Selectivity in Human Posterior Parietal Association Cortex, Neuron, Volume 95, Issue 3, 2 August 2017, Pages 697-708.e4, ISSN 0896-6273, https://doi.org/10.1016/j.neuron.2017.06.040. (http://www.sciencedirect.com/science/article/pii/S0896627317305925)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79265
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:21 Jul 2017 15:50
Last Modified:04 Aug 2017 23:10

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