CaltechAUTHORS
  A Caltech Library Service

The structure of synthetic polypeptides

Pauling, Linus and Corey, Robert B. (1951) The structure of synthetic polypeptides. Proceedings of the National Academy of Sciences of the United States of America, 37 (5). pp. 241-250. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:PAUpnas51b

[img]
Preview
PDF
See Usage Policy.

959Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:PAUpnas51b

Abstract

In a preliminary communication last year(1) we stated that there are only two helical configurations of polypeptide chains in which the residues are all equivalent and intramolecular hydrogen bonds are formed, and in which the interatomic distances, bond angles, and other structural features, especially the coplanarity of the conjugated amide system, are as required by earlier work in these Laboratories on amino acids, simple peptides, and other substances related to protein's. These two helical configurations were described in detail in a later paper(2) and it was mentioned that there is evidence that they occur in α keratin, α myosin, supercontracted keratin and myosin, and other fibrous proteins, and also constitute an important structural feature of hemoglobin and other globular proteins.(3) In the following paragraphs we discuss evidence that one of the helical structures is assumed also by synthetic polypeptides.


Item Type:Article
Additional Information:© 1951 by the National Academy of Sciences. Communicated March 31, 1951. This investigation was aided by grants from The Rockefeller Foundation, The National Foundation for Infantile Paralysis, and The U.S. Public Health Service. Gates and Crellin Laboratories of Chemistry, Contribution No. 1551.
Record Number:CaltechAUTHORS:PAUpnas51b
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:PAUpnas51b
Alternative URL:http://www.pnas.org/cgi/reprint/37/5/241
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8081
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Jul 2007
Last Modified:26 Dec 2012 09:36

Repository Staff Only: item control page