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bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations

Chen, Jeannie and Flannery, John G. and LaVail, Matthew M. and Steinberg, Roy H. and Xu, Jun and Simon, Melvin I. (1996) bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proceedings of the National Academy of Sciences of the United States of America, 93 (14). pp. 7042-7047. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:CHEpnas96a

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Abstract

Apoptosis of photoreceptors occurs infrequently in adult retina but can be triggered in inherited and environmentally induced retinal degenerations. The protooncogene bcl-2 is known to be a potent regulator of cell survival in neurons. We created lines of transgenic mice overexpressing bcl-2 to test for its ability to increase photoreceptor survival. Bcl-2 increased photoreceptor survival in mice with retinal degeneration caused by a defective opsin or cGMP phosphodiesterase. Overexpression of Bcl-2 in normal photoreceptors also decreased the damaging effects of constant light exposure. Apoptosis was induced in normal photoreceptors by very high levels of bcl-2. We conclude that bcl-2 is an important regulator of photoreceptor cell death in retinal degenerations.


Item Type:Article
Additional Information:Copyright © 1996 by the National Academy of Sciences Contributed by Melvin I. Simon, January 26, 1996 We thank Nancy Lawson, Cathy Lau, Gloria Riggs, Douglas Yasumura, and Dr. Michael T. Matthes for technical and secretarial assistance. This research was supported by National Institutes of Health Postdoctoral Fellowship EY06405 (J.C.); Research Grants AG12288 (M.I.S.), EY08908 (J.G.F.), EY01919 (M.M.L.), and EY01429 (R.H.S.); Core Grant EY02162; and funds from the Foundation Fighting Blindness, Research to Prevent Blindness, Alcon Research Institute, and That Man May See, Inc. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:apoptosis, transgenic mice, retina
Record Number:CaltechAUTHORS:CHEpnas96a
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:CHEpnas96a
Alternative URL:http://www.pnas.org/cgi/content/abstract/93/14/7042
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:812
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:07 Oct 2005
Last Modified:26 Dec 2012 08:41

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