Komano, Tohru and Knippers, Rolf and Sinsheimer, Robert L. (1968) The process of infection with bacteriophage phiX174, XXII. Synthesis of progeny single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America, 59 (3). pp. 911-916. ISSN 0027-8424. PMCID PMC224778. http://resolver.caltech.edu/CaltechAUTHORS:KOMpnas68
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In a previous article,(1) it was demonstrated that of the labeled thymidine incorporated into the replicative form (RF) of phiX-DNA during the period of RF replication (3-12 or 15 min after infection), approximately half was transferred to virus during the subsequent period of single-strand DNA synthesis, while half remained in RF molecules. In this paper experiments are presented which permit a definition of the label remaining in the RF and which clarify the role of the RF in the synthesis of the progeny single-stranded DNA.
|Additional Information:||© 1968 by the National Academy of Sciences. Communicated December 20, 1967. We are indebted to Dr. M. Goulian for a generous gift of purified exonuclease III and to Mrs. Louise Wilson for technical assistance. This research was supported in part by grant GM 13554 from the U.S. Public Health Service.|
|PubMed Central ID:||PMC224778|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||21 Aug 2007|
|Last Modified:||16 Dec 2015 20:06|
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