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Internetwork and intranetwork communications during bursting dynamics: Applications to seizure prediction

Feldt, S. and Osterhage, Hannes and Mormann, Florian and Lehnertz, Klaus and Zochowski, M. (2007) Internetwork and intranetwork communications during bursting dynamics: Applications to seizure prediction. Physical Review E, 76 (2). Art. No. 021920. ISSN 1539-3755. http://resolver.caltech.edu/CaltechAUTHORS:FELpre07

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Abstract

We use a simple dynamical model of two interacting networks of integrate-and-fire neurons to explain a seemingly paradoxical result observed in epileptic patients indicating that the level of phase synchrony declines below normal levels during the state preceding seizures (preictal state). We model the transition from the seizure free interval (interictal state) to the seizure (ictal state) as a slow increase in the mean depolarization of neurons in a network corresponding to the epileptic focus. We show that the transition from the interictal to preictal and then to the ictal state may be divided into separate dynamical regimes: the formation of slow oscillatory activity due to resonance between the two interacting networks observed during the interictal period, structureless activity during the preictal period when the two networks have different properties, and bursting dynamics driven by the network corresponding to the epileptic focus. Based on this result, we hypothesize that the beginning of the preictal period marks the beginning of the transition of the epileptic network from normal activity toward seizing.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1103/PhysRevE.76.021920DOIArticle
http://link.aps.org/doi/10.1103/PhysRevE.76.021920PublisherArticle
ORCID:
AuthorORCID
Mormann, Florian0000-0003-1305-8028
Additional Information:© 2007 The American Physical Society (Received 9 March 2007; revised 23 May 2007; published 20 August 2007) S.F. was funded through the National Science Foundation. H.O. and K.L. acknowledge support from the Deutsche Forschungsgemeinschaft (Grant No. SFB-TR3 sub-project A2). F.M. acknowledges support from the European Community 6th Framework Programme, Marie Curie OIF 040445). M.Z. acknowledges support from NIBIB at NIH (Grant No. EB003583).
Group:Koch Laboratory, KLAB
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)SFB-TR3 sub-project A2
Marie Curie Fellowship040445
NIHEB003583
Subject Keywords:neural nets; neurophysiology; seizure
Classification Code:PACS: 87.18.Hf, 87.18.Sn, 05.45.Xt
Record Number:CaltechAUTHORS:FELpre07
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:FELpre07
Alternative URL:http://dx.doi.org/10.1103/PhysRevE.76.021920
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8643
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:02 Sep 2007
Last Modified:08 Feb 2017 17:19

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