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Distribution of endogenous murine leukemia virus DNA sequences among mouse chromosomes

Joloicoeur, Paul and Rassart, Eric and Kozak, Christine and Ruddle, Frank and Baltimore, David (1980) Distribution of endogenous murine leukemia virus DNA sequences among mouse chromosomes. Journal of Virology, 33 (3). pp. 1229-1235. ISSN 0022-538X. http://resolver.caltech.edu/CaltechAUTHORS:JOLjvir80

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Abstract

We used mouse-Chinese hamster somatic cell hybrids which lose mouse chromosomes to examine the distribution of murine leukemia virus DNA sequences in the genome of A/HeJ mice. We analyzed total cellular DNA from various hybrid clones for the presence of viral sequences by molecular hybridization and used the Southern blot hybridization procedure to identify viral DNA in cellular restriction endonuclease fragments. Our results show that murine leukemia virus DNA sequences are distributed among many mouse chromosomes in this strain. Chromosome 4 was shown to contain murine leukemia virus DNA sequences.


Item Type:Article
Additional Information:Copyright © 1980 by the American Society for Microbiology. We thank Peter Shank for his advice on the DNA transfer technique. This project was supported by grants from the National Cancer Institute of Canada and the Medical Research Council to P.J., by Public Health Service grant 09966 to F.R., and by grant VC-4G from the American Cancer Society and Public Health Service grant CA-14051 from the National Cancer Institute to DB.
Record Number:CaltechAUTHORS:JOLjvir80
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:JOLjvir80
Alternative URL:http://jvi.asm.org/cgi/content/abstract/33/3/1229
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8722
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:10 Sep 2007
Last Modified:26 Dec 2012 09:41

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