LaBonne, Carole and Bronner, Marianne E. (1999) Molecular mechanisms of neural crest formation. Annual Review of Cell and Developmental Biology, 15 . pp. 81-112. ISSN 1081-0706. http://resolver.caltech.edu/CaltechAUTHORS:LABarcdb99
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The neural crest is a transient population of multipotent precursor cells named for its site of origin at the crest of the closing neural folds in vertebrate embryos. Following neural tube closure, these cells become migratory and populate diverse regions throughout the embryo where they give rise to most of the neurons and support cells of the peripheral nervous system (PNS), pigment cells, smooth muscle, craniofacial cartilage, and bone. Because of its remarkable ability to generate such diverse derivatives, the neural crest has fascinated developmental biologists for over one hundred years. A great deal has been learned about the migratory pathways neural crest cells follow and the signals that may trigger their differentiation, but until recently comparatively little was known about earlier steps in neural crest development. In the past few years progress has been made in understanding these earlier events, including how the precursors of these multipotent cells are specified in the early embryo and the mechanisms by which they become migratory. In this review, we first examine the mechanisms underlying neural crest induction, paying particular attention to a number of growth factor and transcription factor families that have been implicated in this process. We also discuss when and how the fate of neural crest precursors may diverge from those of nearby neural and epidermal populations. Finally, we review recent advances in our understanding of how neural crest cells become migratory and address the process of neural crest diversification.
|Additional Information:||"Reprinted, with permission, from the Annual Review of Cell and Developmental Biology, Volume 15 copyright 1999 by Annual Reviews, www.annualreviews.org" The authors thank Dr. CD Stern for communicating data prior to publication and Dr. M Dickinson and members of the laboratory for insightful discussions and comments on the manuscript. This work was supported by grants from the American Cancer Society (CL) and National Institutes of Health NS34671 and NS36585 (MBF).|
|Subject Keywords:||BMP, Wnt, FGF, chick, Xenopus|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||12 Sep 2007|
|Last Modified:||26 Dec 2012 09:42|
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