CaltechAUTHORS
  A Caltech Library Service

Evidence for an interrelation in the metabolism of lysine, arginine and pyrimidines in Neurospora

Houlahan, Mary B. and Mitchell, Herschel K. (1948) Evidence for an interrelation in the metabolism of lysine, arginine and pyrimidines in Neurospora. Proceedings of the National Academy of Sciences of the United States of America, 34 (10). pp. 465-470. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:HOUpnas48

[img]
Preview
PDF
See Usage Policy.

651Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:HOUpnas48

Abstract

The behavior of a strain of Neurospora crassa carrying the pyrimidineless gene 3a (37301) and s, a second mutant gene which suppresses the effect of 3a, has been described briefly in an earlier publication.(1) A strain carrying 3a alone has an absolute requirement for pyrimidine, while 3a-s reaches about one-half the maximum growth of the wild type on the un-supplemented basal medium.(2) However, if arginine is present in this medium the pyrimidine requirement is again manifested. The effect of arginine may be suppressed in turn by the addition of lysine. This response to arginine and lysine suggested the possibility that one or both of these amino acids are involved in the biosynthesis of pyrimidines. More recent investigations have provided evidence that a relationship does exist, but its nature is not yet understood.


Item Type:Article
Additional Information:© 1948 by the National Academy of Sciences. Communicated by G. W. Beadle, July 27, 1948. Work supported by grants from the Rockefeller Foundation.
Record Number:CaltechAUTHORS:HOUpnas48
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:HOUpnas48
Alternative URL:http://www.pnas.org/cgi/reprint/34/10/465
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8853
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Sep 2007
Last Modified:14 Nov 2014 19:20

Repository Staff Only: item control page