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On the interactions of lipids and proteins in the red blood cell membrane

Glaser, Michael and Simpkins, Henry and Singer, S. J. and Sheetz, Michael and Chan, Sunney I. (1970) On the interactions of lipids and proteins in the red blood cell membrane. Proceedings of the National Academy of Sciences of the United States of America, 65 (3). pp. 721-728. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:GLApnas70

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Abstract

The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the proteins of the membranes can change structure independently of one another, suggesting a mosaic pattern for the organization of the lipids and proteins in membranes.


Item Type:Article
Additional Information:© 1970 by the National Academy of Sciences. Communicated December 12, 1969. This work was supported in part by U.S.P.H.S. grant GM-15971 to S.J. Singer and U.S.P.H.S. grant GM-14523 and NSF grant GP-8540 to S.I. Chan (Caltech). [M.S. was a] National Institute of Health Predoctoral Trainee, 1969-1970. A.A. Noyes Laboratory of Chemical Physics, Contribution No. 3977.
Record Number:CaltechAUTHORS:GLApnas70
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:GLApnas70
Alternative URL:http://www.pnas.org/cgi/content/abstract/65/3/721
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8966
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Oct 2007
Last Modified:14 Nov 2014 19:20

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