McMahon, Daniel (1973) A cell-contact model for cellular position determination in development. Proceedings of the National Academy of Sciences of the United States of America, 70 (8). pp. 2396-2400. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:MCMpnas73
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The fate of a cell in a developing organism is a function of its position within the organism. The molecular mechanism that cells use to determine their position and to convert positional information into a form that can be used to regulate the expression of genes is not understood. This paper presents a model in which contacts between complementary molecules on plasma membranes of adjacent cells regulate the concentration of a morphogenetic substance and transmit positional information. This model is described by four equations that, when solved with realistic parameters, demonstrated that this mechanism will produce discrete populations of cells within a few hours from an initially undifferentiated array of cells. The model suggests an explanation for several phenomena that have been observed and suggests experiments to test it and to clearly differentiate it from other models for position determination.
|Additional Information:||© 1973 by the National Academy of Sciences. Communicated by Max Delbrück, May 23, 1973. I am grateful to Welcome Bender, Mark Miller, William Quinn, and Randall Cassada for many helpful discussions and to Michael Morgan for writing the computer program. This research was supported by USPHS Grant no. GM 06965.|
|Subject Keywords:||differentiation; plasma membrane; Dictyostelium discoideum; cyclic AMP|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||23 Oct 2007|
|Last Modified:||26 Dec 2012 09:44|
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