Knippers, Rolf and Whalley, J. Millar and Sinsheimer, Robert L. (1969) The process of infection with bacteriophage phiX174, XXX. Replication of double-stranded phiX DNA. Proceedings of the National Academy of Sciences of the United States of America, 64 (1). pp. 275-282. ISSN 0027-8424. PMCID PMC286158. http://resolver.caltech.edu/CaltechAUTHORS:KNIpnas69
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Intermediates involved in the replication of double-stranded phiX174 RF DNA have been identified and partially characterized. Analysis of pulse-labeled RF DNA suggests that the synthesis of progeny RF molecules involves, in part, the addition of nucleotides to linear complementary strands on a circular parental strand as template, so as to produce intermediate DNA strands of greater than viral length. Electron microscopy reveals DNA rings with "tails" and "double rings," which could be the intermediate structures. A model is postulated for the replication process.
|Additional Information:||© 1969 by the National Academy of Sciences. Communicated June 30, 1969. This research was supported in part by grant GM 13554 from the U.S. Public Health Service.|
|PubMed Central ID:||PMC286158|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||25 Oct 2007|
|Last Modified:||16 Dec 2015 20:16|
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