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The process of infection with bacteriophage phiX174, XXX. Replication of double-stranded phiX DNA

Knippers, Rolf and Whalley, J. Millar and Sinsheimer, Robert L. (1969) The process of infection with bacteriophage phiX174, XXX. Replication of double-stranded phiX DNA. Proceedings of the National Academy of Sciences of the United States of America, 64 (1). pp. 275-282. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:KNIpnas69

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Abstract

Intermediates involved in the replication of double-stranded phiX174 RF DNA have been identified and partially characterized. Analysis of pulse-labeled RF DNA suggests that the synthesis of progeny RF molecules involves, in part, the addition of nucleotides to linear complementary strands on a circular parental strand as template, so as to produce intermediate DNA strands of greater than viral length. Electron microscopy reveals DNA rings with "tails" and "double rings," which could be the intermediate structures. A model is postulated for the replication process.


Item Type:Article
Additional Information:© 1969 by the National Academy of Sciences. Communicated June 30, 1969. This research was supported in part by grant GM 13554 from the U.S. Public Health Service.
Record Number:CaltechAUTHORS:KNIpnas69
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:KNIpnas69
Alternative URL:http://www.pnas.org/cgi/content/abstract/64/1/275
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9061
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Oct 2007
Last Modified:26 Dec 2012 09:45

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