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Drosophila lifespan enhancement by exogenous bacteria

Brummel, Ted and Ching, Alisa and Seroude, Laurent and Simon, Anne F. and Benzer, Seymour (2004) Drosophila lifespan enhancement by exogenous bacteria. Proceedings of the National Academy of Sciences of the United States of America, 101 (35). pp. 12974-12979. ISSN 0027-8424.

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We researched the lifespan of Drosophila under axenic conditions compared with customary procedure. The experiments revealed that the presence of bacteria during the first week of adult life can enhance lifespan, despite unchanged food intake. Later in life, the presence of bacteria can reduce lifespan. Certain long-lived mutants react in different ways, indicating an interplay between bacteria and longevity-enhancing genes.

Item Type:Article
Additional Information:Copyright © 2004 by the National Academy of Sciences. Contributed by Seymour Benzer, July 18, 2004. We thank Stephanie Cornelison and John Silverlake for expert technical assistance and Todd Chiche, Jared Leadbetter, Micheline Laurent, and members of the Benzer laboratory for helpful discussions. This work was funded by grants (to S.B.) from the National Science Foundation and the National Institute of Aging. L.S. acknowledges funding from the Natural Sciences Engineering Research Council of Canada and the Institute of Aging of the Canadian Institutes of Health Research.
Subject Keywords:longevity, aging, axenic flies, antibiotics, caenorhabditis-elegans, gene-expression, helicobacter-pylori, innate immunity, ribosomal-RNA, free animals, fat-body, melanogaster, microflora, microbiota
Record Number:CaltechAUTHORS:BRUpnas04
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:911
Deposited By: Tony Diaz
Deposited On:08 Nov 2005
Last Modified:14 Nov 2014 19:18

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