Kindt, Thomas J. and Klapper, David G. and Waterfield, Michael D. (1973) An idiotypic cross-reaction between allotype a3 and allotype a negative rabbit antibodies to streptococcal carbohydrates. Journal of Experimental Medicine, 137 (3). pp. 636-648. ISSN 0022-1007 http://resolver.caltech.edu/CaltechAUTHORS:KINjem73
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Two antibodies to Group C streptococcal carbohydrate isolated from an individual rabbit had similar relative binding affinities for a Group C immuno-adsorbent column. Their light chains were similar, if not identical, as were the constant regions of their heavy chains. Differences in the variable regions of the H chains of the two antibodies were detected by chemical analysis. The two antibodies had serologically identical idiotypic determinants although one antibody possessed the a3 allotype and the other had no detectable group a marker. The occurrence of such antibodies indicates the absence of obligatory associations between group a allotypes and idiotypic specificities, despite the fact that both determinants have antigenic components in the VH region of the H chain.
|Additional Information:||© 1973 by The Rockefeller University Press. (Received for publication 14 November 1972) This work was supported by the National Institutes of Health grants AI 08429 and AI 10781 and by a Grant-in-Aid from the American Heart Association. [T.J.K. was an] Established Investigator, American Heart Association. The authors thank Dr. R.M. Krause for his support and encouragement in all phases of this work. We thank Ms. Rochelle Seide for her skillful and patient assistance in these experiments. The helpful comments of Doctors J.D. Capra, J.M. Kehoe, H.G. Kunkel, and C.W. Todd are gratefully acknowledged.|
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|Deposited On:||29 Oct 2007|
|Last Modified:||26 Dec 2012 09:45|
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