Ellison, Jay and Hood, Leroy (1982) Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. Proceedings of the National Academy of Sciences of the United States of America, 79 (6). pp. 1984-1988. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:ELLpnas82
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We report the nucleotide sequence of a gene encoding a human immunoglobulin Cγ2} region. Comparison with the previously determined Cγ4} sequence reveals that these two genes share extensive (~95%) homology in the three CH domain exons and adjacent noncoding regions. In contrast, hinge exons have diverged to a much greater degree, implying that natural selection has favored the generation of diversity in these coding regions. We have used the noncoding nucleotide differences to estimate that approximately 6-7 million years have elapsed since the occurrence of the gene duplication or correction event which generated the two identical ancestral genes. In addition we show that the two Cγ genes are arranged in human chromosomal DNA in the configuration 5'-Cγ2}-17 kilobase pairs -Cγ4}-3'.
|Additional Information:||© 1982 by the National Academy of Sciences. Communicated by Norman Horowitz, November 23, 1981. We thank Karyl Minard for excellent technical assistance and Bernita Larsh for the preparation of the manuscript. This work was supported by Grant GM 20927 from the National Institutes of Health and National Research Service Award 1T32 GM07616 from the National Institute of General Medical Sciences to J.E. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.|
|Subject Keywords:||evolution; gene duplication; unequal crossover; gene conversion|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||31 Oct 2007|
|Last Modified:||26 Dec 2012 09:45|
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