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Transient expression and transport of brain-derived neurotrophic factor in the male zebra finch's song system during vocal development

Akutagawa, Eugene and Konishi, Masakazu (1998) Transient expression and transport of brain-derived neurotrophic factor in the male zebra finch's song system during vocal development. Proceedings of the National Academy of Sciences of the United States of America, 95 (19). pp. 11429-11434. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:AKUpnas98

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Abstract

The distribution of brain-derived neurotrophic factor (BDNF) in the song system of male zebra finches changes with posthatching age. At day 20, the hyperstriatum ventrale, pars caudale is the only song nucleus in which neurons showed BDNF immunoreactivity. At day 45, the staining in hyperstriatum ventrale, pars caudale was denser than at day 20 and the robust nucleus of the archistriatum, another song nucleus, showed BDNF labeling. By day 65, two additional song nuclei, area X and the lateral magnocellular nucleus of the anterior neostriatum, have become immunoreactive. In the adult, however, the amount of BDNF labeling in all of these brain nuclei is sharply reduced. These sequential events, the anatomical connections between these song nuclei, and the labeling of relevant axons and terminals suggest anterograde transport of BDNF. Furthermore, the timing of BDNF expression coincident with the development of singing behavior suggests that this neurotrophin may be directly involved with the differentiation of the song system.


Item Type:Article
Additional Information:Copyright © 1998 by the National Academy of Sciences. Contributed by Masakazu Konishi, July 29, 1998. We are grateful to Dr. Q. Yan of Amgen for his generous gift of the BDNF polyclonal antibody. We also thank Paul Patterson for his critical reading of the manuscript. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:CENTRAL-NERVOUS-SYSTEM, FOREBRAIN NUCLEUS, ANTEROGRADE TRANSPORT, DENDRITIC GROWTH, VISUAL-SYSTEM, NEURONS, BDNF, DEATH, DIFFERENTIATION, PLASTICITY
Record Number:CaltechAUTHORS:AKUpnas98
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:AKUpnas98
Alternative URL:http://www.pnas.org/cgi/content/abstract/95/19/11429
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:927
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Nov 2005
Last Modified:26 Dec 2012 08:42

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