Hewlett, Martinez J. and Rose, John K. and Baltimore, David (1976) 5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proceedings of the National Academy of Sciences of the United States of America, 73 (2). pp. 327-330. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:HEWpnas76
![[img]](http://authors.library.caltech.edu/style/images/fileicons/application_pdf.png)
|
PDF
See Usage Policy. 1271Kb |
Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:HEWpnas76
Abstract
Poliovirus RNA purified from virus-specific polyribosomes does not contain m7G in a 5'-5'-pyrophosphate linkage at its 5'-end. The only potential 5'-end found in ribonuclease digests of this RNA is pUp, which is present in a yield of 1 mole/mole of poliovirus RNA. We conclude that a 5'-terminal m7G is not required for translation of at least one RNA species in animal cells.
| Item Type: | Article |
|---|---|
| Additional Information: | © 1976 by the National Academy of Sciences. Contributed by David Baltimore, November 10, 1975. This work was supported by Grants #AI08388, CA 12174, and CA 14051 from the National Institutes of Health. M.J.H. is a Postdoctoral Fellow of the American Cancer Society. J.K.R. is a Postdoctoral Fellow of the National Cystic Fibrosis Research Foundation. D.B. is a Research Professor of the American Cancer Society. |
| Subject Keywords: | DEAE-paper ionophoresis; mRNA; 7-methylguanosine in 5'-5'-pyrophosphate linkage |
| Record Number: | CaltechAUTHORS:HEWpnas76 |
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:HEWpnas76 |
| Alternative URL: | http://dx.doi.org/10.1073/pnas.73.2.327 |
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
| ID Code: | 9274 |
| Collection: | CaltechAUTHORS |
| Deposited By: | Tony Diaz |
| Deposited On: | 05 Dec 2007 |
| Last Modified: | 26 Dec 2012 09:47 |
Repository Staff Only: item control page
