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Replicative form II DNA of phiX174; Resistance to exonucleolytic cleavage by E. coli DNA polymerase

Razin, Aharon and Sinsheimer, Robert L. (1970) Replicative form II DNA of phiX174; Resistance to exonucleolytic cleavage by E. coli DNA polymerase. Proceedings of the National Academy of Sciences of the United States of America, 66 (3). pp. 646-650. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:RAZpnas70

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Abstract

The progeny replicative form II DNA isolated from E. coli cells infected with phiX174 is resistant to the exonucleolytic activity associated with E. coli DNA polymerase. A limited endonucleolytic cleavage with micrococcal endonuclease renders the replicative form II molecule susceptible to the exonucleolytic activity associated with the E. coli DNA polymerase. These experiments suggest that the resistance of the replicative form II DNA to the exonucleolytic activity is a result of the structure of these molecules at their 5'-terminus.


Item Type:Article
Additional Information:© 1970 by the National Academy of Sciences. Communicated April 15, 1970. This research was supported in part by a grant from the U.S. Public Health Service GM-13534 and a postdoctoral research fellowship 1 F05, TW-1348 to A.R.
Record Number:CaltechAUTHORS:RAZpnas70
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:RAZpnas70
Alternative URL:http://www.pnas.org/cgi/content/abstract/66/3/646
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9301
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Dec 2007
Last Modified:14 Nov 2014 19:20

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