Razin, Aharon and Sinsheimer, Robert L. (1970) Replicative form II DNA of phiX174; Resistance to exonucleolytic cleavage by E. coli DNA polymerase. Proceedings of the National Academy of Sciences of the United States of America, 66 (3). pp. 646-650. ISSN 0027-8424 http://resolver.caltech.edu/CaltechAUTHORS:RAZpnas70
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Abstract
The progeny replicative form II DNA isolated from E. coli cells infected with phiX174 is resistant to the exonucleolytic activity associated with E. coli DNA polymerase. A limited endonucleolytic cleavage with micrococcal endonuclease renders the replicative form II molecule susceptible to the exonucleolytic activity associated with the E. coli DNA polymerase. These experiments suggest that the resistance of the replicative form II DNA to the exonucleolytic activity is a result of the structure of these molecules at their 5'-terminus.
| Item Type: | Article |
|---|---|
| Additional Information: | © 1970 by the National Academy of Sciences. Communicated April 15, 1970. This research was supported in part by a grant from the U.S. Public Health Service GM-13534 and a postdoctoral research fellowship 1 F05, TW-1348 to A.R. |
| Record Number: | CaltechAUTHORS:RAZpnas70 |
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:RAZpnas70 |
| Alternative URL: | http://www.pnas.org/cgi/content/abstract/66/3/646 |
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. |
| ID Code: | 9301 |
| Collection: | CaltechAUTHORS |
| Deposited By: | Tony Diaz |
| Deposited On: | 12 Dec 2007 |
| Last Modified: | 26 Dec 2012 09:47 |
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