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The action of certain substituted phenols on marine eggs in relation to their dissociation

Tyler, Albert and Horowitz, Norman H. (1937) The action of certain substituted phenols on marine eggs in relation to their dissociation. Proceedings of the National Academy of Sciences of the United States of America, 23 (7). pp. 369-374. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:TYLpnas37

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Abstract

It has been shown by Clowes and Krahl (1, 2) that various substituted phenols as well as dinitrophenol increase the respiratory rate of marine eggs. Also, the highly interesting reversible block to cleavage, which they found to occur at the maximum of respiratory stimulation, is likewise exhibited. The different substances (nitro- and halo-phenols and cresols in particular) used were found to be active in different concentrations, and some attempt is made to relate the activity to molecular structure. The degree of dissociation of the phenolic OH is taken to be of no significance in their experiments. There has been some controversy concerning this question. Field, Martin and Field (3, 4) showed that in yeast the amount of respiratory stimulation by 2,4-dinitrophenol and by 4,6-dinitrocresol depends upon the concentration of the undissociated form present, similar calculated concentrations of undissociated DNP giving at different pH's the same stimulation. Citing their own experiments and those of Ehrenfest and Ronzoni (5) on yeast, De Meio and Barron (6), on the other hand, disagree with this conclusion.


Item Type:Article
Additional Information:Copyright © 1937 by the National Academy of Sciences. Communicated June 7, 1937. William G. Kerckhoff Laboratories of the Biological Sciences, California Institute of Technology.
Record Number:CaltechAUTHORS:TYLpnas37
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:TYLpnas37
Alternative URL:http://www.pnas.org/content/vol23/issue7/
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:935
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Nov 2005
Last Modified:14 Nov 2014 19:18

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