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Biological inorganic chemistry at the beginning of the 21st century

Gray, Harry B. (2003) Biological inorganic chemistry at the beginning of the 21st century. Proceedings of the National Academy of Sciences of the United States of America, 100 (7). pp. 3563-3568. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:GRApnas03

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Abstract

Advances in bioinorganic chemistry since the 1970s have been driven by three factors: rapid determination of high-resolution structures of proteins and other biomolecules, utilization of powerful spectroscopic tools for studies of both structures and dynamics, and the widespread use of macromolecular engineering to create new biologically relevant structures. Today, very large molecules can be manipulated at will, with the result that certain proteins and nucleic acids themselves have become versatile model systems for elucidating biological function.


Item Type:Article
Additional Information:Copyright © 2003 by the National Academy of Sciences. Many thanks to Peter Brzezinski, Angelo Di Bilio, Alex Dunn, Jenn Lee, Ed Stiefel, Akif Tezcan, and Jay Winkler for assistance with references and figures as well as helpful discussions; and to the National Science Foundation, the National Institutes of Health, and the Arnold and Mabel Beckman Foundation for research support.
Subject Keywords:CYTOCHROME-C-OXIDASE, MOLYBDENUM-IRON PROTEIN, RAPID KINETIC-ANALYSIS, ELECTRON-TRANSFER, RHODOBACTER-SPHAEROIDES, PROTON TRANSLOCATION, ANGSTROM RESOLUTION, INTERACTION DOMAIN, REACTION-MECHANISM, OXYGEN ACTIVATION
Record Number:CaltechAUTHORS:GRApnas03
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:GRApnas03
Alternative URL:http://dx.doi.org/10.1073/pnas.0730378100
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:938
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:15 Nov 2005
Last Modified:14 Nov 2014 19:18

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