Davidson, Eric H. and McClay, David R. and Hood, Leroy (2003) Regulatory gene networks and the properties of the developmental process. Proceedings of the National Academy of Sciences of the United States of America, 100 (4). pp. 1475-1480. ISSN 0027-8424. PMCID PMC149855. http://resolver.caltech.edu/CaltechAUTHORS:DAVpnas03
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Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.
|Additional Information:||Copyright © 2003 by the National Academy of Sciences. We thank Dr. Ellen Rothenberg for a perspicacious and useful review of a draft of the manuscript. This research was supported by National Institutes of Health Grants HD-37105, GM-61005, RR-06591, and RR-15044, National Aeronautics and Space Administration Grant NAG2-1368, and the Lucille P. Markey Trust.|
|Subject Keywords:||sea-urchin embryo, beta-catenin, cell fates, specification, differentiation, mechanisms, micromeres, hindbrain, Krox-20, Spotx|
|PubMed Central ID:||PMC149855|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Tony Diaz|
|Deposited On:||15 Nov 2005|
|Last Modified:||23 Dec 2015 23:40|
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