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Strategies for studying permeation at voltage-gated ion channels

Lester, Henry A. (1991) Strategies for studying permeation at voltage-gated ion channels. Annual Review of Physiology, 53 . pp. 477-496. ISSN 0066-4278. http://resolver.caltech.edu/CaltechAUTHORS:LESarp91

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Abstract

Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways. This chapter focuses on permeation pathways and may spur new ideas about experiments that use site-directed mutagenesis to probe the ion conduction pathway. Some hubris is required to attempt a survey of this field since individual families -- K^+, Na^+, or Ca^(2+) -- have been reviewed in detail (15, 68, 115, 127). My unified treatment is motivated by the structural similarity suggested by recent cDNA sequencing data on this group (see, for instance, 24). There have been many excellent previous treatments of ion channel permeation (6, 15, 34, 35, 51, 53, 68, 73, 74, 115, 127).


Item Type:Article
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http://dx.doi.org/10.1146/annurev.ph.53.030191.002401)DOIUNSPECIFIED
http://arjournals.annualreviews.org/doi/abs/10.1146%2Fannurev.ph.53.030191.002401PublisherUNSPECIFIED
Additional Information:"Reprinted, with permission, from the Annual Review of Physiology, Volume 53 copyright 1991 by Annual Reviews, www.annualreviews.org". I thank R. Aldrich and R. MacKinnon for sharing their work prior to publication, P. Lazarow for challenges on rectification, and N. Davidson, B. Hille, T. Begenisich, and members of my research group for many helpful comments. Preparation of this review was supported by grants from the Klingenstein Foundation, the Muscular Dystrophy Association, and the National Institutes of Health (GM-29836 and NS-11756).
Funders:
Funding AgencyGrant Number
Klingenstein FoundationUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
NIHGM-29836
NIHNS-11756
Subject Keywords:HETEROLOGOUS EXPRESSION; SODIUM POTASSIUM CALCIUM CHANNEL EXCITABLE MEMBRANES; LOCAL ANESTHETICS; SITE-DIRECTED MUTAGENESIS
Record Number:CaltechAUTHORS:LESarp91
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:LESarp91
Alternative URL:http://dx.doi.org/10.1146/annurev.ph.53.030191.002401
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9487
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Jan 2008
Last Modified:26 Dec 2012 09:49

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