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Recovery of protein synthesis after heat shock: Prior heat treatment affects the ability of cells to translate mRNA

Petersen, Nancy S. and Mitchell, Herschel K. (1981) Recovery of protein synthesis after heat shock: Prior heat treatment affects the ability of cells to translate mRNA. Proceedings of the National Academy of Sciences of the United States of America, 78 (3). pp. 1708-1711. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:PETpnas81

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Abstract

A mild heat shock at 35 degrees C, which induces heat shock gene expression, greatly enhances survival and the recovery of protein synthesis in Drosophila cells after a higher temperature heat shock. The 35 degrees C treatment is also effective in preventing heat-induced developmental defects in pupae. We show here that the major larval mRNAs are present in approximately normal (25 degrees C) concentrations after a 40.1 degrees C heat shock whether or not the animals receive a pretreatment. This indicates that the pretreatment affects translation directly rather than messenger concentration. We also observe selective translation of heat shock messages and some 25 degrees C messages during recovery from heat shock.


Item Type:Article
Additional Information:© 1981 by the National Academy of Sciences. Communicated by Norman Davidson, November 24, 1980. This work was supported by U.S. Public Health Service Grants GM 25966A-01 and AG 01931A-01.
Subject Keywords:thermal tolerance; translational regulation
Record Number:CaltechAUTHORS:PETpnas81
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:PETpnas81
Alternative URL:http://www.pnas.org/cgi/content/abstract/78/3/1708
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9553
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Feb 2008
Last Modified:14 Nov 2014 19:20

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