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Polypeptide cleavages in the formation of poliovirus proteins

Jacobson, Michael F. and Baltimore, David (1968) Polypeptide cleavages in the formation of poliovirus proteins. Proceedings of the National Academy of Sciences of the United States of America, 61 (1). pp. 77-84. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:JACpnas68

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Abstract

The final step in poliovirus morphogenesis appears to be the combination of viral RNA with a protein shell called the procapsid.(1) Concomitant with the union of the RNA and the procapsid there is a cleavage of one of the procapsid proteins, producing two of the four proteins of the virion. We have now found that cleavages play an important role in the formation of most if not all poliovirus-specific proteins. Although most mammalian messenger RNA's appear to be monocistronic, it seems possible that a cleavage mechanism may function in the synthesis of some mammalian cell proteins.


Item Type:Article
Additional Information:© 1968 by the National Academy of Sciences. Communicated by S.E. Luria, July 15, 1968. This work was supported by grant AI-08388 from the USPHS and grant E-512 from the American Cancer Society. M.F.J. was a recipient of a predoctoral training grant from the NIH (no. 5-F1-GM-34, 102). D.B. received a Faculty Research Award from the American Cancer Society.
Record Number:CaltechAUTHORS:JACpnas68
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:JACpnas68
Alternative URL:http://dx.doi.org/10.1073/pnas.61.1.77
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9675
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Feb 2008
Last Modified:26 Dec 2012 09:51

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