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Carbon-13 nuclear magnetic resonance spectroscopy. Structure of the anticoagulant warfarin and related compounds in solution

Giannini, Donald D. and Chan, Kenneth K. and Roberts, John D. (1974) Carbon-13 nuclear magnetic resonance spectroscopy. Structure of the anticoagulant warfarin and related compounds in solution. Proceedings of the National Academy of Sciences of the United States of America, 71 (10). pp. 4221-4223. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:GIApnas74

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Abstract

Carbon-13 nuclear magnetic resonance spectra have been obtained for the coumarin-related compounds warfarin and phenprocoumon. The spectral assignments indicate that warfarin exists as a mixture of cyclic hemiketal diastereomers in dimethyl sulfoxide solution. The sodium salt of warfarin exists as the ring-open form in water solution.


Item Type:Article
Additional Information:© 1974 by the National Academy of Sciences. Contributed by John D. Roberts, August 6, 1974. This work was supported by the Public Health Service, Research Grant GM-11072, from the Division of General Medical Sciences, and by the National Science Foundation. This paper is contribution no. 4941 from the Gates and Crellin Laboratories of Chemistry, California Institute of Technology.
Subject Keywords:coumarin-related compounds; phenprocoumon
Record Number:CaltechAUTHORS:GIApnas74
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:GIApnas74
Alternative URL:http://www.pnas.org/cgi/content/abstract/71/10/4221
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9789
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Mar 2008
Last Modified:26 Dec 2012 09:52

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