Raghavan, Malini and Bjorkman, Pamela J. (1996) Fc receptors and their interactions with immunoglobulins. Annual Review of Cell and Developmental Biology, 12 . pp. 181-220. ISSN 1081-0706 http://resolver.caltech.edu/CaltechAUTHORS:BJOarcdb96
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Receptors for the Fc domain of immunoglobulins play an important role in immune defense. There are two well-defined functional classes of mammalian receptors. One class of receptors transports immunoglobulins across epithelial tissues to their main sites of action. This class includes the neonatal Fc receptor (FcRn), which transports immunoglobulin G (IgG), and the polymeric immunoglobulin receptor (pIgR), which transports immunoglobulin A (IgA) and immunoglobulin M (IgM). Another class of receptors present on the surfaces of effector cells triggers various biological responses upon binding antibody-antigen complexes. Of these, the IgG receptors (FcγR) and immunoglobulin E (IgE) receptors (FcεR) are the best characterized. The biological responses elicited include antibody-dependent, cell-mediated cytotoxicity, phagocytosis, release of inflammatory mediators, and regulation of lymphocyte proliferation and differentiation. We summarize the current knowledge of the structures and functions of FcRn, pIgR, and the FcγR and FcεRI proteins, concentrating on the interactions of the extracellular portions of these receptors with immunoglobulins.
|Additional Information:||"Reprinted, with permission, from the Annual Review of Cell and Developmental Biology, Volume 12 copyright 1996 by Annual Reviews, www.annualreviews.org" We thank Dan Vaughn and Bob Turring for help with figures, Neil Simister and Sally Ward for communicating results prior to publication and for helpful discussions, Sherie Morrison and Dan Vaughn for helpful discussions, and Dan Vaughn and Luis Sanchez for critical reading of the manuscript. MR was supported by a fellowship from the Cancer Research Institute. PJB is supported by the Howard Hughes Medical Institute and a Camille and Henry Dreyfuss Teacher Scholar Award. Ribbon diagrams were prepared using MOLSCRIPT (Kraulis 1991).|
|Subject Keywords:||immunoglobulin gene superfamily, structure, binding, transcytosis, effector functions|
|Usage Policy:||No commercial reproduction, distribution, display or performance rights in this work are provided.|
|Deposited By:||Archive Administrator|
|Deposited On:||18 Nov 2005|
|Last Modified:||26 Dec 2012 08:42|
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