CaltechAUTHORSDevelopment of NG2 neural progenitor cells requires Olig gene functionKeith L.LigonauthorSantoshKesariauthorMasaakiKitadaauthorTaoSunauthorHeather A.ArnettauthorJohn A.AlbertaauthorDavid J.AndersonauthorCharles D.StilesauthorDavid H.RowitchauthorIn the adult central nervous system, two distinct populations of glial cells expressing the chondroitin sulfate proteoglycan NG2 have been described: bipolar progenitor cells and more differentiated "synantocytes." These cells have diverse neurological functions, including critical roles in synaptic transmission, repair, and regeneration. Despite their potential importance, the genetic factors that regulate NG2 cell development are poorly understood, and the relationship of synantocytes to the oligodendroglial lineage, in particular, remains controversial. Here, we show that > 90% of embryonic and adult NG2 cells express Olig2, a basic helix-loop-helix transcription factor required for oligodendrocyte lineage specification. Analysis of mice lacking Olig function demonstrates a failure of NG2 cell development at embryonic and perinatal stages that can be rescued by addition of a transgene containing the human OLIG2 locus. These findings show a general requirement for Olig function in NG2 cell development and highlight further roles for Olig transcription factors in neural progenitor cells.Caltech Library Services2006-05-16Article

For work being deposited by its own author: In self-archiving this collection of files and associated bibliographic metadata, I grant CaltechAUTHORS the right to store them and to make them permanently available publicly for free on-line. I declare that this material is my own intellectual property and I understand that CaltechAUTHORS does not assume any responsibility if there is any breach of copyright in distributing these files or metadata. (All authors are urged to prominently assert their copyright on the title page of their work.)

For work being deposited by someone other than its author: I hereby declare that the collection of files and associated bibliographic metadata that I am archiving at CaltechAUTHORS) is in the public domain. If this is not the case, I accept full responsibility for any breach of copyright that distributing these files or metadata may entail.

Clicking on the deposit button indicates your agreement to these terms.