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Impacts of Caffeine during Pregnancy

Qian, Jingjing and Chen, Qi and Ward, Sean M. and Duan, Enkui and Zhang, Ying (2020) Impacts of Caffeine during Pregnancy. Trends in Endocrinology & Metabolism, 31 (3). pp. 218-227. ISSN 1043-2760. PMCID PMC7035149.

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A growing, robust body of evidence from both epidemiological and animal studies unveils harmful effects of maternal gestational caffeine exposure, even from doses previously considered 'safe.' Rodent studies revealed that caffeine exposure during specific stages of pregnancy may disrupt embryo transport, embryo development, embryo implantation, and placental function, leading to pregnancy complications. Notably, caffeine sensitivity is highly variable from individual to individual. Genetic variations and epigenetic regulation, intermingling with intrinsic and environmental factors, might play pivotal roles in shaping the complex phenotypic variability. Exploring the underlying mechanism(s) will be helpful, not only for improving the guidelines of gestational caffeine consumption, but also for personalized dosing of drugs that interact with caffeine at the pharmacokinetic or pharmacodynamic level. Evidence from rodent studies demonstrated that in utero caffeine exposure triggered cardiometabolic defects on both the immediate offspring and subsequent generations. Further studies are needed regarding caffeine’s long-term effects and multigenerational influence in humans.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Chen, Qi0000-0001-6353-9589
Additional Information:© 2019 Elsevier Ltd. Available online 6 December 2019.
Funding AgencyGrant Number
National Basic Research Program of China2019YFA0802600
National Natural Science Foundation of China31671201
Chinese Academy of Sciences2016081
Nevada Women’s Health Initiative FundUNSPECIFIED
Subject Keywords:caffeine; oviductal transport; embryo development; embryo implantation; epigenetic variation; epigenetic inheritance
Issue or Number:3
PubMed Central ID:PMC7035149
Record Number:CaltechAUTHORS:20191209-084353784
Persistent URL:
Official Citation:Jingjing Qian, Qi Chen, Sean M. Ward, Enkui Duan, Ying Zhang, Impacts of Caffeine during Pregnancy, Trends in Endocrinology & Metabolism, Volume 31, Issue 3, 2020, Pages 218-227, ISSN 1043-2760, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100232
Deposited By: Tony Diaz
Deposited On:09 Dec 2019 17:57
Last Modified:09 Mar 2020 13:18

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