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Setting up for gastrulation: D. melanogaster

Stathopoulos, Angelike and Newcomb, Susan (2019) Setting up for gastrulation: D. melanogaster. In: Gastrulation: From Embryonic Pattern to Form. Current Topics in Developmental Biology. No.136. Academic Press , Cambridge, pp. 3-32. ISBN 978-0-12-812798-8. https://resolver.caltech.edu/CaltechAUTHORS:20191213-150530214

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Abstract

Drosophila melanogaster embryos develop initially as a syncytium of totipotent nuclei and subsequently, once cellularized, undergo morphogenetic movements associated with gastrulation to generate the three somatic germ layers of the embryo: mesoderm, ectoderm, and endoderm. In this chapter, we focus on the first phase of gastrulation in Drosophila involving patterning of early embryos when cells differentiate their gene expression programs. This patterning process requires coordination of multiple developmental processes including genome reprogramming at the maternal-to-zygotic transition, combinatorial action of transcription factors to support distinct gene expression, and dynamic feedback between this genetic patterning by transcription factors and changes in cell morphology. We discuss the gene regulatory programs acting during patterning to specify the three germ layers, which involve the regulation of spatiotemporal gene expression coupled to physical tissue morphogenesis.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/bs.ctdb.2019.11.004DOIArticle
ORCID:
AuthorORCID
Stathopoulos, Angelike0000-0001-6597-2036
Newcomb, Susan0000-0002-8563-9422
Additional Information:© 2019 Elsevier. Available online 12 December 2019.
Subject Keywords:Drosophila melanogaster; Gastrulation; Embryonic development; Syncytium; Maternal-to-zygotic transition; Anterior-posterior patterning; Dorsal-ventral patterning; Germ-band elongation; Morphogen gradients; Mesoderm; Endoderm; Ectoderm
Series Name:Current Topics in Developmental Biology
Issue or Number:136
Record Number:CaltechAUTHORS:20191213-150530214
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191213-150530214
Official Citation:Angelike Stathopoulos, Susan Newcomb, Chapter One - Setting up for gastrulation: D. melanogaster, Editor(s): Lilianna Solnica-Krezel, Current Topics in Developmental Biology, Academic Press, Volume 136, 2020, Pages 3-32, ISSN 0070-2153, ISBN 9780128127988, https://doi.org/10.1016/bs.ctdb.2019.11.004. (http://www.sciencedirect.com/science/article/pii/S0070215319300912)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100294
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:16 Dec 2019 16:44
Last Modified:21 Jan 2020 18:53

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