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Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression

McDonel, Patrick and Guttman, Mitchell (2019) Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression. Cold Spring Harbor Perspectives in Biology, 11 (12). Art. No. a032151. ISSN 1943-0264. PMCID PMC6886450. https://resolver.caltech.edu/CaltechAUTHORS:20191218-091029384

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Abstract

Mammalian genomes encode tens of thousands of long noncoding RNAs (lncRNAs) that have been implicated in a diverse array of biological processes and human diseases. In recent years, the development of new tools for studying lncRNAs has enabled important progress in defining the mechanisms by which Xist and other lncRNAs function. This collective work provides a framework for how to define the mechanisms by which lncRNAs act. This includes defining lncRNA function, identifying and characterizing lncRNA–protein interactions, and lncRNA localization in the cell. In this review, we discuss various experimental approaches for deciphering lncRNA mechanisms and discuss issues and limitations in interpreting these results. We explore what these data can reveal about lncRNA function and mechanism as well as emerging insights into lncRNA biology that have been derived from these studies.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/cshperspect.a032151DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6886450/PubMed CentralArticle
ORCID:
AuthorORCID
Guttman, Mitchell0000-0003-4748-9352
Additional Information:© 2019 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/).
Issue or Number:12
PubMed Central ID:PMC6886450
Record Number:CaltechAUTHORS:20191218-091029384
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191218-091029384
Official Citation:Approaches for Understanding the Mechanisms of Long Noncoding RNA Regulation of Gene Expression Patrick McDonel and Mitchell Guttman Cold Spring Harb Perspect Biol December 2019;11:a032151 First published online December 2, 2019 doi:10.1101/cshperspect.a032151
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100342
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Dec 2019 17:31
Last Modified:04 May 2020 20:21

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