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A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound

Schibber, E. F. and Mittelstein, D. R. and Gharib, M. and Shapiro, M. G. and Lee, P. P. and Ortiz, M. (2020) A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound. Proceedings of the Royal Society A: Mathematical, physical, and engineering sciences, 476 (2236). Art. No. 20190692. ISSN 1364-5021. PMCID PMC7209139. https://resolver.caltech.edu/CaltechAUTHORS:20191223-114059821

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Abstract

The method of oncotripsy, first proposed in Heyden & Ortiz (Heyden & Ortiz 2016 J. Mech. Phys. Solids 92, 164–175 (doi:10.1016/j.jmps.2016.04.016)), exploits aberrations in the material properties and morphology of cancerous cells in order to ablate them selectively by means of tuned low-intensity pulsed ultrasound. We propose the dynamical model of oncotripsy that follows as an application of cell dynamics, statistical mechanical theory of network elasticity and ‘birth–death’ kinetics to describe the processes of damage and repair of the cytoskeleton. We also develop a reduced dynamical model that approximates the three-dimensional dynamics of the cell and facilitates parametric studies, including sensitivity analysis and process optimization. We show that the dynamical model predicts—and provides a conceptual basis for understanding—the oncotripsy effect and other trends in the data of Mittelstein et al. (Mittelstein et al. 2019 Appl. Phys. Lett. 116, 013701 (doi:10.1063/1.5128627)), for cells in suspension, including the dependence of cell-death curves on cell and process parameters.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1098/rspa.2019.0692DOIArticle
https://arxiv.org/abs/1911.12407arXivDiscussion Paper
https://doi.org/10.1016/j.jmps.2016.04.016DOIHeyden & Ortiz 2016 J. Mech. Phys. Solids 92, 164–175
https://doi.org/doi:10.1063/1.5128627DOIMittelstein et al. 2019 Appl. Phys. Lett. 116, 013701
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc7209139/PubMed CentralArticle
ORCID:
AuthorORCID
Schibber, E. F.0000-0002-6629-297X
Mittelstein, D. R.0000-0001-8747-0483
Gharib, M.0000-0002-2204-9302
Shapiro, M. G.0000-0002-0291-4215
Ortiz, M.0000-0001-5877-4824
Alternate Title:A Dynamical Model of Oncotripsy by Mechanical Cell Fatigue: Selective Cancer Cell Ablation by Low-Intensity Pulsed Ultrasound (LIPUS)
Additional Information:© 2020 The Author(s). Published by the Royal Society. Manuscript received 18/10/2019; Manuscript accepted 23/03/2020; Published online 29/04/2020; Published in print 29/04/2020. Data accessibility: This article has no additional data. Authors' contributions: M.O. conceived the study. E.F.S. and M.O. developed the theory and drafted the manuscript with input from all authors. All authors discussed the manuscript and gave final approval for publication. We declare we have no competing interests. The support of the California Institute of Technology through the Rothenberg Innovation Initiative and through the Caltech–City of Hope Biomedical Research Initiative is gratefully acknowledged.
Group:GALCIT
Funders:
Funding AgencyGrant Number
Rothenberg Innovation Initiative (RI2)UNSPECIFIED
Caltech-City of Hope Biomedical InitiativeUNSPECIFIED
Subject Keywords:oncotripsy, ultrasound, low-intensity pulsed ultrasound, biomechanics, fatigue
Issue or Number:2236
PubMed Central ID:PMC7209139
Record Number:CaltechAUTHORS:20191223-114059821
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20191223-114059821
Official Citation:Schibber EF, Mittelstein D, Gharib M, Shapiro M, Lee P, Ortiz M. 2020 A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound. Proc. R. Soc. A 476: 20190692. http://dx.doi.org/10.1098/rspa.2019.0692
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100410
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Dec 2019 21:39
Last Modified:08 Jun 2020 16:46

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