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Neural Network Training Data Profoundly Impacts Texture-Based Intravascular Image Segmentation

Gowrishankar, Akshay and Athanasiou, Lambros S. and Olender, Max L. and Edelman, Elazer R. (2019) Neural Network Training Data Profoundly Impacts Texture-Based Intravascular Image Segmentation. In: 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE). IEEE , Piscataway, NJ, pp. 989-993. ISBN 978-1-7281-4617-1.

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Segmentation of variably differentiated and low-frequency elements in a complex image is challenging. Improving sensitivity demands often prohibitive decreases in specificity. This is particularly the case in intravascular imaging, where detection of heterogeneously dispersed lesion elements, which are often less evident than normal structures, is essential. Modalities including optical coherence tomography (OCT) provide cross-sectional images of coronary arteries that reveal atherosclerotic plaques. Manual plaque segmentation is time consuming and error prone; automated methods are quicker but dictate accuracy tradeoffs. We developed a neural network-based method for automatic detection of calcified plaques in OCT images using texture-based features and examined how underlying training data distribution impacts sensitivity and predictive value. The method assesses each pixel, rather than a patch, as an independent unit, enabling precise control of training data distribution while simultaneously decreasing reliance on massive imaging datasets for training. Pixels from 30 manually annotated OCT images of calcified plaques were used to train the neural network. Several texture measures were computed for the local neighborhood of each pixel and used as inputs to a multi-layered neural network. The ratio of pixels of each class in the training dataset was then varied and the resulting network performance was compared. Positive predictive value and sensitivity ranged from 0.69 to 0.77 and 0.35 to 0.86, respectively, as the ratio of non-calcified to calcified pixels varied from around 15 to 1, with inverse changes in specificity. The results clearly demonstrate that appropriately balanced data must be carefully curated with thoughtful consideration of the model's application and the clinical imperative being addressed.

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Additional Information:© 2019 IEEE. Funding in part was provided by the U.S. National Institutes of Health (R01 49039) to ERE. The authors thank Dr. José M. de la Torre Hernández (Hospital Universitario Marqués de Valdecilla, Santander, Spain) for providing the annotated clinical imaging data.
Funding AgencyGrant Number
NIHR01 49039
Subject Keywords:optical coherence tomography, neural network, training data, atherosclerotic plaque, calcified plaque
Record Number:CaltechAUTHORS:20200103-104239037
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Official Citation:A. Gowrishankar, L. Athanasiou, M. Olender and E. Edelman, "Neural Network Training Data Profoundly Impacts Texture-Based Intravascular Image Segmentation," 2019 IEEE 19th International Conference on Bioinformatics and Bioengineering (BIBE), Athens, Greece, 2019, pp. 989-993. doi: 10.1109/BIBE.2019.00184
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:100497
Deposited By: Tony Diaz
Deposited On:05 Jan 2020 00:13
Last Modified:16 Nov 2021 17:54

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